Cortical plasticity following intramuscular lidocaine injection

ABSTRACT BACKGROUND AND OBJECTIVES: The manipulation of peripheral neuronal activity can alter the excitability primary motor cortex; however, it is not known whether this occurs after intramuscular injections lidocaine. Therefore, investigation focused on neurophysiological changes, assessed with transcranial magnetic stimulation, lidocaine (0.5mL, 2%) injection in first dorsal interosseous muscle dominant hand healthy individuals. METHODS: Exploratory, double-blind, parallel laboratory study. Twenty-eight subjects (mean age: 29.6 years, 15 women). Measurements stimulation included resting threshold, evoked potential, intracortical facilitation, and short inhibition. Lidocaine (LID group) was compared to dry needling (DRY group), saline (SAL no intervention (CTL group). Participants were randomly placed each group. Muscle strength measures (rheobase chronaxie) also evaluated detect interventions generated changes neuromuscular excitability. Evaluations performed over four time points: immediately before 30 60 minutes intervention. RESULTS: A generalized linear model used identify differences between LID, DRY, SAL groups CTL results showed that potentials modified LID group (p<0.005). CONCLUSION: into adults alters potentials.